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Approaches: abdominal, laparoscopic, robotic assistance, hysteroscopic The method chosen depends on fibroid size, number, location, patient health, and fertility plans

Specific examples of methylation in detoxification: Arsenic detoxification requires sequential methylation: arsenite to monomethylarsonic acid to dimethylarsinic acid (the excretable form), catalyzed by arsenic methyltransferase (AS3MT) using SAM-e R Mercury undergoes methylation by gut bacteria, converting inorganic mercury to more toxic methylmercury (this is detrimental methylation, not detoxification) R COMT methylation of 4-hydroxy catechol estrogens prevents them from forming reactive quinones that generate ROS and DNA damage R 6

However other solutes in the sample will typically be eluted or washed off

New challenges such as HIV-1 and M.tb co-infections in TB patients, multi-drug resistant (MDR), and extensively drug resistant (XDR) strains of M.tb have also emerged recently